American Society for Clinical Pathology (ASCP) Technologist in Cytogenetics certification (ASCP CG) Practice Test

What outcome can be expected from chromosomal collapse during banding procedures?

1. Visible centromeres

2. Loss of genetic information

3. Clearer banding patterns

4. Increased chromosome visibility

The correct answer is: Clearer banding patterns

The expected outcome of chromosomal collapse during banding procedures is clearer banding patterns. Chromosomal collapse refers to the process where chromosomes, typically in a condensed state during cell division, become more organized during the banding technique. This organization allows for distinct bands to become visible, which represent variations in chromatin density and help in the identification of specific chromosomal regions and abnormalities. A clearer banding pattern is crucial for cytogenetic analysis, as it enhances the ability to distinguish individual chromosomes and elucidate their structures. This increased clarity is particularly important during karyotyping and in identifying translocations, deletions, or other chromosomal anomalies. While the presence of distinct banding patterns enhances visibility, the other potential outcomes, such as the visibility of centromeres or loss of genetic information, pertain to different aspects of the chromosomal structure and stability rather than the direct result of chromosomal collapse during the banding technique.