American Society for Clinical Pathology (ASCP) Technologist in Cytogenetics certification (ASCP CG) Practice Test

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Which of the following accurately describes the state of chromosomal changes in AML M0 and M1?

Both have significant chromosomal variations
Neither shows any chromosomal changes
Both types are associated with chromosomal stability
Only one of the two types displays chromosomal anomalies

The correct answer is: Neither shows any chromosomal changes

The state of chromosomal changes in Acute Myeloid Leukemia (AML) M0 and M1 is characterized by their relative lack of significant chromosomal anomalies. Specifically, AML M0, classified as minimally differentiated acute myeloid leukemia, and AML M1, classified as acute myeloid leukemia with myeloid differentiation, can often present with minimal or no specific chromosomal abnormalities detectable by standard cytogenetic methods. While there can be exceptions and some patients might exhibit chromosomal changes, it is widely noted that a significant number of cases in these subtypes either lack distinct abnormalities or show a limited variety of chromosomal changes compared to other subtypes of AML. This crucial characteristic helps in understanding the clinical behavior and prognostic implications of these particular types of leukemia. Consequently, recognizing that neither AML M0 nor M1 shows significant chromosomal changes is essential for accurate diagnosis and treatment planning in these conditions.