American Society for Clinical Pathology (ASCP) Technologist in Cytogenetics certification (ASCP CG) Practice Test

Which statement is true regarding chromosomal changes in AML types?

1. AML M0 is always associated with chromosomal changes

2. AML M1 is characterized by significant chromosomal alterations

3. Both AML M0 and M1 lack associated chromosomal changes

4. AML M0 shows occasional chromosomal changes

The correct answer is: Both AML M0 and M1 lack associated chromosomal changes

In acute myeloid leukemia (AML), particularly in subtypes M0 and M1, the presence or absence of chromosomal changes can play a significant role in understanding the disease's genetics and behavior. For AML M0, it is typically characterized by a lack of specific chromosomal abnormalities, which can make it more difficult to ascertain than other subtypes that may have more prominent genetic markers. Subtypes of AML, like M0, are often diagnosed based on morphological criteria along with immunophenotyping rather than being heavily characterized by chromosomal alterations. Although AML M1 can exhibit some chromosomal abnormalities, they are not necessarily as significant or distinct as those found in other AML subtypes. Therefore, the assertion that both AML M0 and M1 lack associated chromosomal changes highlights the understanding that while there may be genetic presentations, they aren't necessarily defined by chromosomal alterations, making it a more accurate reflection of the current knowledge regarding these specific types of AML.